摘要
p21^(WAF1/CIP1)基因参与多条信号通路,在细胞周期、细胞分化及凋亡等重要的细胞活动中具有重要作用。文章对p21(WAF1/CIP1)基因转录调控机制及其与肿瘤的关系进行阐述,以进一步明确其在肿瘤诊断、治疗和预后评价中的应用价值。
p21^(WAF1/CIP1) gene is a target of diverse signal pathways that regulate cell cycle,differentiation and apoptosis.In this review,we summarized the mechnisms about p53-dependent and-independent transcrip- tional regulation of p21^(WAF1/CIP1) promoter and its relevance with cancer.Further identification of factors that af- fect p21^(WAF1/CIP1) gene and its correlation with cancer is likely to contribute the better understanding of its impor- tance in cancer.
出处
《肿瘤研究与临床》
CAS
2007年第3期207-211,共5页
Cancer Research and Clinic
基金
国家自然科学基金重点资助项目(30430710)
