胃癌前病变患者胃内理化因素的研究

To study the relationship of the physical and chemical factors in the stomach with precancerous lesions.

目的研究胃内理化因素与胃癌前病变的关系。方法回顾分析1987年10月至2005年5月海南省三亚市人民医院1092例因上消化道症状做胃镜检查患者的胃内理化因素的检查结果。结果胃癌前病变(PCG)、非癌前病变(NPCG)和正常胃(NG)胃内理化因素前瞻性相关对比分析研究发现:PCG 者胃液 pH 较 NG、NPCG 者增高。随 pH 增高,胃幽门螺杆菌培养阳率、菌株数、菌量、菌类及产生亚硝基化合物菌株亦增加,与 pH值正相关(r=0.81.P<0.01)。另外,胃黏膜的机械性损伤也增加癌前病变的发生。结论 PCG 者胃内理化因素存在着形成致癌质的内在环境,治疗 PCG 有防癌的意义。

Objective to study the relationship of the physical and chemical factors in the stomach with precancerous lesions.Methods retrospectively analyzed the results of the above tested factors in the stomach of the 1092 cases of pa- tients that had been done the endoscopic check-up due to the upper abdominal distresses.Results the physical and chemical factors in the stomach with precancerous lesions(PCL),non-precancerous lesions(NPCL)and in normal stom- ach(NS)were analyzed by retrospective cohort study and we found that the pH in the stomach with PCL was higher than that in NS and of the stomach with NPCL.With the pH increasing,the positive rates、numbers、quantities and species of the bacteria as well as the bacteria brought up nitrate compound increased,which were positively relevant with pH(r= 0.81,P<0.01).Furthermore,the gastric mechanical damage could also intensify the formation of the PCL.Conclusion the changes of the physical and chemical factors in the stomach with PCL could lead to the cancer of stomach and the treatment of PCL could prevent it.