幽门螺杆菌感染与胃癌的关系

The relahiws between he Ilico bacter pylors and Cancer of Stomach.

目的研究幽门螺杆菌(HP)感染与胃癌前病变及胃癌的关系。方法回顾性分析了三亚市人民医院1992年3月至2004年3月5216例因上消化道症状做胃镜患者的 HP 检测及胃黏膜病理学检查结果。结果HP 总检出率为45.8%,萎缩性胃炎、肠化生及异型增生的 HP 检出率显著高于 HP 总检出率(P<0.05),上述3种胃癌前变之间 HP 检出率无显著差异,HP 阳性患者3种癌前病变的发生率显著高于 HP 阴性患者(P<0.01),萎缩性胃炎和肠化生的发生年龄亦显著提早;HP 阳性患者在3种癌前病变的程度上与 HP 阴性患者无显著差异(P>0.05),随着病变程度的加重,HP 检出率逐渐下降;HP 阳性患者的肠化类型与 HP 阴性患者差异无显著性意义(P>0.05)。结论 HP 感染与胃癌密切相关,HP 感染主要作用于癌前病变的起始阶段。

Objective Purpose:In order to study the relations between hellicobacter pyiori(HP)and cancer of stomach, we should first study the relations between HP and precancerous lesions.Methods we respectively analyzed the results of HP and gastric membraneous pathologic biopsy of 5216 cases who were undergone the endoscopic examination suffered from upper gastro-intestinal distress.Results The HP was found at the average rate of 45.8%.However,the infection rates of HP of the patients with atrophic gastritis,intestinal metaplasia,as well as atypical hyperplasia were much more higher than the average rate(P<0.05).The HP positive rates above-mentioned 3 kinds of cancerous lesions showed no difference.The positive rates of cancerous lesions of HP positive patients were much more higher than HP negative ones(P <0.01).Moreover,The HP positive patients with atrophic gastritis,intestinal metaplasia were younger.The degrees of cancerous lesions of the HP positive patients were not significantly different from the HP negative ones(P>0.05).With the progress of cancerous lesions,the positive rate was decreased gradually.The types of intestinal metaplasia of HP posi- tive patients were not different from the negative ones(P>0.05).Conclusion The HP infection was closely related with the stomach cancer.The HP infection worked on the initial stage of cancerous lesions.