基团保护法合成高纯度单硬脂酸甘油酯

Synthesis of high-purity glycerin monostearate by group protection method

硬脂酸与缩酮化羟基保护中间体1,2-异亚丙基甘油在催化剂作用下经酯化、水解得到高纯度的单硬脂酸甘油酯。在适宜的反应条件下:1,2-异亚丙基甘油与硬脂酸的摩尔比为1.2∶1,催化剂用量为2%(以1,2-异亚丙基甘油的质量计),环己烷带水,反应时间为6 h,反应温度为90℃,单硬脂酸甘油酯收率达93.64%。

The high-purity glycerin monostearate is preparated by stearic acid with hydroxyl protection intermediates 1,2-isoprpylidene glycerol after esterification and hydrolysis.Under the optional conditions as reaction temperature 90℃,mole ratio of 1,2-isoprpylidene glycerol to stearic acid 1.2∶1,reaction time 6 h and mass of catalyst to 1,2-isoprpylidene glycerol 2%,the yield of glycerin monostearate can be 93.64%.