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Effect of Simvastatin on IL-6 and Adiponectin Secretion and mRNA Ex- pression in 3T3-L1 Adipocytes 被引量：1

Effect of Simvastatin on IL-6 and Adiponectin Secretion and mRNA Ex- pression in 3T3-L1 Adipocytes
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摘要 In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimu- lated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P<0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P<0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes. In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimu- lated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P<0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P<0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.
作者 殷晓明 涂玲 杨慧清
机构地区 Departmentof Geriatric Medicine Department of Integration
出处 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2007年第3期248-251,共4页 华中科技大学学报（医学英德文版）
关键词 obesity ADIPOCYTE ADIPONECTIN SIMVASTATIN INTERLEUKIN-6 obesity adipocyte adiponectin simvastatin interleukin-6
分类号 R96 [医药卫生—药理学]
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参考文献9

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  • 4C. Moro,E. Klimcakova,K. Lolmède,M. Berlan,M. Lafontan,V. Stich,A. Bouloumié,J. Galitzky,P. Arner,D. Langin.Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue[J]. Diabetologia . 2007 (5)
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  • 6Wong GW,Krawczyk SA,Kitidis-Mitrokostas C,et al.Identification and characterization of CTRP9,a novel secreted glycoprotein,from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. The FASEB Journal . 2009
  • 7Li S,Shin HJ,Ding EL,et al.Adiponectin levels and risk of type 2 diabetes:A systematic review and meta-analysis. The Journal of The American Medical Association . 2009
  • 8Wolk R,Berger P,Lennon RJ,et al.Association between plasma adiponectin levels and unstable coronary syndromes[J ]. European Heart Journal . 2007
  • 9Langheim S,Dreas L,Veschini L,et al.Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome[J ]. American Journal of Physiology Heart and Circulatory Physiology . 2010
  • 10Roubícek T,DolinkováM,Bláha J,et al.Increased angiotensinogen production in epicardial adipose tissue during cardiac surgery:possible role in a postoperative insulin resistance. J Physiol Res . 2008

引证文献1

Journal of Huazhong University of Science and Technology(Medical Sciences)
2007年 第3期

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