血清δ胆红素检测的临床意义研究

Detection of serum δ bilirubin and its clinical significance

目的探讨高胆红素血症中δ胆红素检测的临床应用价值。方法利用干化学法对临床多型黄疸患者和正常人血清进行胆红素检测,并用SPSS软包对数据作统计分析。结果与正常参考组δ胆红素相比较,高未结合胆红素血症组差异无显著性(p>0.05),高结合胆红素血症组差异具高度显著性(p<0.001)。高未结合胆红素血症组δ胆红素均小于高结合胆红素血症组差异具高度显著性(p<0.001);梗阻性高胆红素血症组与其它疾病组比较具有高度显著性差异(p<0.001)。结论δ胆红素检测对各型黄疸鉴别诊断和病程、预后判断具有重要临床价值。

Objective To investigate the value of δ bilirubin detection in patients with hyperbilirubinemia.Methods Serum samples from patients with various types of hyperbilirubinemia and healthy individuals were detected by dry chemistry for bilirubin concentration.SPSS software was used for data analysis.Results There was no significant difference in δ bilirubin level between the unconjugated hyperbilirubinemia group and the control(p>0.05).In patents with conjugated hyperbilirubinemia,the level was markedly increased(p<0.001).There was significant difference in the level between the unconjugsted hyperbilitalbinomia group and conjugated hyperbilirubinemia group(p<0.001).Remarkable difference in the level was found between the patients with obstructive hyperbilirubinemia and those with other types of hyperbilirubinemia(p<0.001).Conclusions Detection of δ bilirubin is very important for differential diagnosis of hyperbilirubinemia and evaluation disease course and liver function in the patients.