缺血性脑血管病患者血浆溶血磷脂酸及血小板CD62p检测的临床研究

Clinical investigation of plasma Lysophosphatisic acid and platelet membrane CD62p levels in patients with ischemic cerebrovascular

目的 观察智暂性脑缺血发作(TIA)和脑梗死(CI)患者血浆溶血磷脂酸(LPA)的变化,探讨其在缺血性脑血管发生发展以及早期诊断中的临床意义。方法 对78例TIA患者、6 3例脑梗死患者及4 .便健康人分别抽取静脉血,以比色法检测血浆LPA ,同时用流式细胞仪法检测CD6 2p水平,并分析其相关性。结果 TIA组、CI组血浆LPA及血小板CD6 2p水平均显著高于对照组(p <0 .0 1)。而TIA组与脑梗死组比较:血浆LPA水平TIA组明显高于脑梗死组(p <0 .0 1) ;血小板CD6 2p水平,两组之间无显著差(p >0 .0 5 )。结论 血浆LPA和CD6 2p在缺血性脑血管病的发生发展中具有重要作用,检测这些指标。

Objective To explore the changes of plasma Lysophosphatisic acid(LPA) level in patients with transient ischemic atteaks(TIA) or cerebric infarction(CI).And to value the effect of those in the formation and progress of those diseases.Methods: In 78 cases of TIA,63 cases of CI,and 40 healthy people as the control group,the plasma LPA was determined by colorimetry,and the level of platelet membrane CD62p was measured with flow-cytometry.Results: In both the groups of TIA and CI,the levels of LPA and platelet membrane CD62p were significantly higher than those in the control group,respectively(p<0.01).Compared with those in TIA group,the level of LPA in TIA group was significantly higher(p<0.01).And there was no significant difference between the levels of platelet membrane CD62p in the groups of TIA and CI(p>0.05).Conclusions: Plasma Lysophosphatisicacid(LPA) and platelet membrane CD62p have an important effect on t he formation and progress of Ischemic cerebrovascular.And the detection of those targets can be an important guidance to the eralier diagnosis of TIA,control of CI incidence and the treatment of those diseases.