卤代苯对江水细菌的慢性毒性

Chronic Toxicity of Chlorobenzenes to River Bacteria

毒性数据是对化学品进行环境风险评价的基础,慢性毒性数据更能真实的反映毒物对水生生物生长、繁殖及生理功能产生的影响。本文采用细菌生长抑制实验,测定了17种卤代苯对长江水中混合细菌的慢性毒性,得到-lgNOEC值,毒性范围在4.27(氯苯)~5.22(1,2,4-三氯苯)之间。选用量化参数对毒性数据进行定量结构活性关系(QSAR)研究,结果表明,卤代苯对江水细菌的慢性毒性主要与化合物分子的空间大小有关,量化参数范德华面积(SVdW)及分子生成热(Hf)能够很好的描述卤代苯对江水细菌的慢性毒性。

The toxicity data were the foundation of carrying on environmental risk assessment for the chemicals.Chronic toxicity data could truly reflect the influence of poisonous substance to growth,multiplication and physiological function of the aquatic organism.The toxicity-lgNOEC of 17 chlorobenzenes to the bacteria in the Yangtze River was determined by using the bacteria growth inhibition test,and the range of toxicity was from 4.27 for chlorobenzene to 5.22 for 1,2,4-trichlorobenzene.The quantitative structure-activity relationship(QSAR) models were developed for the toxicity by using Quantum chemical descriptors.The results indicated that the chronic toxicity to the river bacteria was mainly related to the size of space of molecule.The chronic toxicity of chlorobenzenes to the river bacteria was described perfectly by Vander waals area of Quantum chemical descriptors(S_(VdW)) and(H_f).