膳食黑米皮抑制载脂蛋白E基因缺陷小鼠动脉粥样斑块的形成

Dietary Black Rice Outlayer Fraction Inhibits Atherosclerotic Plaque Formation in apo E-deficient Mice

目的 研究膳食黑米皮对载脂蛋白E(apoE)基因缺陷小鼠动脉粥样斑块形成的影响 ,探讨黑米皮的抗动脉粥样硬化作用以及可能的活性物质。方法 在apoE基因缺陷小鼠饲料 (AIN -93 )中添加 5 %黑米皮 ,喂养小鼠16周后 ,检测不同实验组小鼠主动脉窦动脉粥样斑块面积。结果 黑米皮组小鼠主动脉窦动脉粥样斑块面积占管腔面积百分比的均值低于阳性组和白米皮组 ,差异有显著性 (P <0 0 5 ) ,黑米皮组的主动脉窦动脉粥样斑块面积分别比阳性组与白米皮组低 48 42 %和 46 0 8%。结论 膳食黑米皮可以抑制apoE基因缺陷小鼠动脉粥样斑块的形成 ,具有抗动脉粥样硬化作用。

Objective To explore the effect of dietary black rice outlayer fraction(BRF)on atherosclerotic plaque formation in apo E-deficient mice and to find the possible active components of BRF in anti-atherogenesis. Methods After 16 weeks intervention by 5% BRF,atherosclerotic plaque area in aortic sinus were assessed through the method of image analysis. Results The plaque area in aortic sinus in mice fed BRF diet was 48.42% and 46.08% less compared to positive group and WRF group respectively. Conclusion This result suggests that BRF has the capacity of inhibiting the atherosclerotic plaque formation and progression in apoE-deficient mice.