妊娠高血压综合征患者凝血功能分子标志物水平的变化及临床意义

The changes and clinical significance of mlolecular markers on coagulation function in patients with pregnancy induced hypertension

目的 探讨孕妇血浆凝血酶原片段F1+2、凝血酶-抗凝血酶复合物(TAT)、可溶性纤维蛋白单体复合物(SFMC)水平的变化与妊娠高血压综合征(妊高征)的关系及其临床意义。方法应用ELISA法对50例正常妊娠妇女、85例妊高征患者及50例正常非孕妇女血中F1+2、TAT及SFMC含量进行测定。结果 正常晚孕组及妊高征各组F1+2、TAT、SFMC含量均明显高于对照组,差异有显著性(P<0.05或P<0.01);轻度妊高征组与正常晚孕组比较无显著性差异(P>0.05);中度及重度妊高征组与正常晚孕组比较亦有显著性差异(P<0.05或P<0.01);且随病情加重含量有升高趋势。结论 正常晚孕妇女凝血功能增强,存在明显的高凝状态,而在妊高征时更为严重。

Objective To study the changes and clinical significance of molecular markers on coagulation function in patients with pregnancy induced hypertension (PIH). Methods Plasma prothrolmbin fragment 1 + 2 (F1 + 2)、thrombin- antithrombin complex (TAT) 、 soluble fibrinomonomer compound(SFMC) were detected by ELISA method in 50 non-pregnancy 、50 normal pegnancy women and 85 patients with pregnancy induced hypertension(PIH) .Results We found that in normal late pregnancy women and in PIH group F1+ 2、TAT、SFMC were obviously higher than those of control group (P < 0.05 or P < 0.01). In moderate and severe PIH patients the parameters were significantly increased compared with those in normal late pregnancy group(P< 0.05 or P< 0.01). But in mild PIH group were not(P>0.05). Conclusions This tell us that hypercoagulable state was shown in normal late pregnancy women. Obvious hypercoagulable state was shown in patients with pregnancy induced hypertension (PIH) .