肿瘤坏死因子、NK细胞亚群对药物流产后阴道流血的影响

The Effect of TNF - α and NK cell subunits on the Continuous Vaginal Bleeding after Drug Abortion

目的 探讨早孕妇女蜕膜中肿瘤坏死因子(TNF-α)和自然杀伤(NK)细胞亚群对药物流产后持续性阴道流血的影响。方法 采用流式细胞技术分析研究60例药物流产后持续性阴道流血患者蜕膜中TNF-α和NK细胞亚群的表达(观察组)。并以60例正常药物流产患者为对照(对照组)。结果 观察组蜕膜中TNF-α表达降低为10.23±1.20％,对照组20.51±6.42％,两组比较有显著性差异(P<0.01)。观察组蜕膜中NK细胞亚群CD56+CD16-、CD56+CD16-、CD56-CD16+的表达降低,分别为9.21±1.25％、2.32±0.78％、3.43±0.42％,,对照组分别为15.97±4.21％、5.32±0,98％、6.12±1.35％,两组比较有显著性差异(P<0.01;P<0.05;P<0.01)。结论 蜕膜中TNF-α和NK细胞亚群的表达降低,致孕囊与蜕膜剥离不全,从而引起持续性阴道流血以及阴道出血量多。

Objective To explore the effect of TNF -α and NK cell subunits on the continuous vaginal bleeding after drug abortion. Methods TNF - α and NK cell subunits in decidua were detected by flow cytometry in 60 cases, and the same amount of cases served as controls . Results The expression of TNF- α in decidua was 10.23 ± 1.20% , compared to 20.51 ± 6.42% in the control. There was significantly different between them(P< 0.01). The value of NK cell subunits CD56+CD16- ,CD56+CD16 + XD56-CD16+ were 9.21 ± 1.25%,2.32± 0.78% ,3.43 ±0.42% respectively.While the rates of the controls were 15.97 ± 4.21% ,5.32 @ 0.98% ,6.12 ± 1.35% respctively, And there was significantly different between the two groups(P< 0.01 ;P< 0.05; P< 0.01) . Cnnclusion The decreasing expression of TNF- α and NK cell subunits,resulting in incomplete denudation of conceptuses,can cause continuous vaginal bleeding after drug abortion.