窒息新生儿肾功能损害多项指标动态观察及临床意义

Dynamic observation and the clinic significance of multi - index of the damage in the function of kidney in the asphyxial blessed event

目的 比较反映室息新生儿肾功能损害的实验室指标差异的临床意义。方法测定窒息新生儿(40例)生后第1天、3天、7天的血、尿β-微球蛋白(β2-MG),血尿素氮(BUN),血肌酐(Cr)的水平。结果 窒息组血β2-MG第1天开始升高,第3天、第7天明显高于对照组(P【0.05),尿β2-MG第1天、第3天明显高于对照组(P【0.05),血BUN、Cr第3天达高峰,而后明显下降,但仍高于对照组(P【0.01)。窒息组各项检测指标的异常发生率明显高于对照组(P【0.05),同一组内尿β2-MG的异常发生率高于血β2~MG、BUN、Cr的异常发生率(P【0.05)。结论 窒息后新生儿肾功能改变呈显著性变化,尿β2-MG检测是判断窒息后新生儿肾损害的敏感指标。

Objective To find the significance of index of the damage in the function of kidney in the asphyxial blessed event. Methods The β- microglobin(β2- MG)in blood and in urine, Urea Nitrogen of Blood(BUN)and Creatinine(Cr) in the blood of 40 asphyxial blessed event bom of 1st day and of 3rd day and of 7th day are determined. Results β2 - MG in blood of the asphyxial group begines to ascend in 1st day and much more than the healthy group in 3rd and 7th day( P < 0.05 ) . The BUN and Cr in blood topped in 3rd day and went down remarkably, but much more than the healthy group yet(P< 0.05) .The occurrence rate of abnormity2 of the multi - index in the asphyxial group is much higher than healthy group( P < 0.05 ) . And the occurrence rate of abnormity of β2 - MG in urine is much higher than that of β2 - MG in blood and that of BUN and that of Cr in blood(P< 0.05) . Conclusions The function of kidney in the asphyxial blessed event channged remarkably. The of β2 - MG in urine is the sensitive index to judge the damage of kidney in the asphyxial blessed event.