胸水与血清CYFRA21-1、CEA、NSE测定对肺癌的诊断价值

The significance of CYFRA21-1、CEA and NSE in pleural effusion and serum for the diagnosis of lung cancer

目的 探讨胸水和血清肿瘤标志物癌胚抗原 (CEA)、神经元特异性烯醇化酶 (NSE)、细胞角蛋白 19片段(CYFRA2 1- 1)在肺癌诊断中的临床价值。方法 采用电化学发光法测定 6 4例肺癌、36例良性肺病 (BLD)患者胸水和血清中CEAA、NSE、CYFRA2 1- 1水平。结果 肺癌患者血清中CEA、CYFRA2 1- 1、NSE的测定值分别为 34.99± 70 .5 2ng/ml、2 0 .5 7±2 8.8ng/ml、36 .2 1± 4 9.19ng/ml;而胸水中分别为 2 2 5 .36± 4 0 7.4 9ng/ml、134.38± 2 6 3.0 0ng/ml、74 .2 2± 119.0 5ng/ml,各项指标的统计学检验均有显著差异 (p <0 .0 1)。三者联合检测在胸水与血清中的阳性率分别为 98.4 4 %和 81.2 5 %。胸水中CEA、CYFRA2 1- 1和NSE在腺癌、鳞癌及非小细胞性肺癌的阳性率 (分别为 83.14 %、95 %、10 0 % )高于血清 (分别为 6 4 .2 9%、80 %、75 % )。结论 胸水CEA、NSE、CYFRA2 1-

Objective To investigate the clinical value of pleural effusion and serum tumor markers including carcinoembryonic antigen(CEA), Neuron-specific enolase(NSE) and cytokeratin 19 fragment(CYFRA21-1) for the diagnosis of lung cancer. Method The level of CEA, NSE and CYFRA21-1 in the pleural effusion and serum of 64 patients with lung cancer and 36 patients with benign lung diseases(BLD) were measured by method of Electrochemiluminescence.Results The values of CEA,CYFRA21-1, NSE were 82.14%、95%、100%,respectively in pleural effusion and 225.36±407.49ng/ml、134.38±263.00ng/ml、74.22±119.05ng/ml,respectiyely in serum of the patients with lung cancer. The statistically significant difference were found for the values of these three markers between pleural effusion and serum. The positive rate of combined detection in pleural effusion and serum for diagnosis of lung cancer was 98.44% and 81.25% respectively.The positive rate of CEA,CYFRA21-1,NSE for diagnosis of SQ,AD and SCLC was 34.99±70.52ng/ml、20.57±28.8ng/ml、36.21±49.19ng/ml,respectively in pleural effusion and 64.29%、80%、75%,respectively in serum.Conclusion Detection of CEA、 CYFRA21-1 and NSE in pleural effusion were of important clinical significance in diagnosis of lung cancer.