口腔鳞状细胞癌的超微结构观察

Ultrastructural Observation of Human Oral Squamous Cell Carcinoma

20例口腔鳞癌做电镜检直。浸润间质散在的癌细胞常无基底膜形成,桥粒减少。在癌巢周边者多有基底膜形成,但多处见伪足状突起突破基底膜,有时见多层基底膜或基底膜样物质沉着。癌巢中常见不全角化珠形成,有分化潜能的肿瘤细胞能模拟人正常口腔粘膜无角化上皮的分化过程,出现单根网状张力细丝,致密核心型膜被颗粒以及椭圆形高密度透明角质蛋白颗粒,这种分化多不完全和紊乱。有的癌细胞含多种类型膜被颗粒一包括中间型者。角化倾向的癌细胞核内见多种类型核小体,本文简单地讨论了核小体与单纯癌疹病毒感染及其和鳞癌发生的关系。

Twenty surgical specimens of ora1 squamous-cell carcinoma were processed for electron microscopy. Free tumour cells infiltrating stroma always lost basal lamina and were shortage of desmosome. In the carcinoma nest, the interface between the tumour cells and stroma exhibited a basal lamina.Basal laminn was absent in many areas where pseudopodal cytoplasmic projections were presented. Sometimes, reduplicated basal lamina and basal lamina-like material were observed. In the nests Where the parakeratinized peatls were formed, the differential capacity of tumour cells mimiced the differentiation of normal human oral non-keratinized epithelium, although it is incomplete and disorder. A few tumour cells contained more than one kinds of monbrane—coating granules, including an intermediate form.A variety of nuclear bodies existed in the tumour cells which were inclined to differentiate into horny pearls. The relationship of Herpes simplex virus infection and type 1V～V nuclear body as well as its contribution to the genesis of oral carcinoma were briefly discussed.