摘要
Objective To access an ideal procedure terminating missed abortion within 12 weeks of gestational age. Methods Women with intrauterine fetal death were randomized into 3 groups. Group A （n=30）： vaginal misoprostol （MP） 0.4 mg, 3 h before vacuum aspiration; group B（n=15）： vaginal MP 0.4 mg every 3 h, up to 5 doses; group C（n=30）： oral mifepristone （MF） 200 mg 36-48 h before vaginal MP 0.4 mg, MP was given every 3 h, up to 5 doses. Results Women in group A had the shortest interval of gestation tissue expulsion （3.2± 0.5 h） and the bleeding （3.2 ± 5.7 ml） during medical procedure, which were statistically significant in comparison with the other two groups （P〈0.001, P〈0.01, respectively）. Success rates of groups A, B and C were 100%, 33.3% and 90.0%, respectively. Percentages of women need surgical interventions were similar in group B and group C（80.0%,76.7%, respectively）. Bleeding during operation, pain after medical procedure and satisfaction presented no statistical significance among the 3 groups. Conclusion Vaginal MP followed by vacuum aspiration was valuable in safety, and efficacy, which led to less bleeding and a faster recovery.
Objective To access an ideal procedure terminating missed abortion within 12 weeks of gestational age. Methods Women with intrauterine fetal death were randomized into 3 groups. Group A （n=30）： vaginal misoprostol （MP） 0.4 mg, 3 h before vacuum aspiration; group B（n=15）： vaginal MP 0.4 mg every 3 h, up to 5 doses; group C（n=30）： oral mifepristone （MF） 200 mg 36-48 h before vaginal MP 0.4 mg, MP was given every 3 h, up to 5 doses. Results Women in group A had the shortest interval of gestation tissue expulsion （3.2± 0.5 h） and the bleeding （3.2 ± 5.7 ml） during medical procedure, which were statistically significant in comparison with the other two groups （P〈0.001, P〈0.01, respectively）. Success rates of groups A, B and C were 100%, 33.3% and 90.0%, respectively. Percentages of women need surgical interventions were similar in group B and group C（80.0%,76.7%, respectively）. Bleeding during operation, pain after medical procedure and satisfaction presented no statistical significance among the 3 groups. Conclusion Vaginal MP followed by vacuum aspiration was valuable in safety, and efficacy, which led to less bleeding and a faster recovery.
