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erbB-3结合蛋白——ebp1的研究进展 被引量:1

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摘要 ebp1——erbB-3结合蛋白(erbB-3bindingprotein)是近年发现的一种新型蛋白质,与细胞周期、蛋白质转录翻译相关,参与多个信号传导通路,影响细胞增殖、分化,但其确切的作用机制尚不明确。本文将对ebp1的蛋白质性质、特点及其生物学活性作用作一综述。
作者 余优成
出处 《国际口腔医学杂志》 CAS 2004年第S1期188-191,共4页 International Journal of Stomatology
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同被引文献11

  • 1Marques MM,Martins MD,Frana CM.Effect of Matrigel on adenoid cystic carcinoma cell line differentiation[J].Int J Exp Pathol,2006,87(6):405-410.
  • 2Yoo JY,Wang XW,Rishi AK,et al.Interaction of the PA2G4 (ebp1) protein with erbB-3 and regulation of this binding by heregulin[J].Br J Cancer,2000,82:683-690.
  • 3Horvath BM,Magyar Z,Zhang Y,et al.ebp1 regulates organ size through cell growth and proliferation in plants[J].EMBO J,2006,25(20):4 909-4 920.
  • 4Zhang Y,Wang XW,Jelovac D,et al.The erbB3-binding protein ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells[J].Proc Natl Acad Sci USA,2005,102(28):9 890-9 895.
  • 5Barnes L,Eveson JW,Reichart P,et al.Pathology and genetics of head and neck tumours[J].IARC Press (Lyon),2005:209-282.
  • 6Liu Z,Oh SM,Okada M,et al.Human BRE1 is an E3 ubiquitin ligase for ebp1 tumor suppressor[J].Mol Biol Cell,2009,20(3):757-768.
  • 7Zhou X,Chen W,Zhang Y,et al.Potential therapeutic strategy for oral squamous cell carcinoma by erbB3-binding protein 1 gene transfer[J].J Cancer Res Clin Oncol,2010,136(6):891-896.
  • 8Xia X,Cheng A,Lessor T,et al.ebp1,an erbB-3 binding protein,interacts with Rb and affects Rb transcriptional regulation[J].J Cell Physiol,2001,187(2):209-217.
  • 9Zhang Y,Lu Y,Zhou H,et al.Alterations in cell growth and signaling in erbB3 binding protein-1 (ebp1) deficient mice[J].BMC Cell Biol,2008,9:69.
  • 10Yu Y,Chen W,Zhang Y,et al.Suppression of salivary adenoid cystic carcinoma growth and metastasis by erbB3 Binding protein ebp1 transfer[J].Int J Cancer,2007,120(9):1 909-1 913.

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