慢性乙型肝炎的抗病毒治疗探讨

Study on the Therapy Against Virus for Chronic Hepatitis B

目的 探讨应用小剂量干扰素(IFN)联合阿昔洛韦(Acyclovir)、单用IFN、一般护肝治疗药物三种方法治疗慢性乙肝的疗效。方法 将选择的84例病人随机分为三组,联合组32例应用IFNlmu+Acyclovir0.75;单用组21例,应用IFN 3mu;护肝组31例,应用肝炎灵针4ml;疗程均为3个月。观察临床,ALT和病毒复制指标变化。结果 三组均能减轻或消除肝炎症状,改善肝功,ALT腹常率在治疗后2个月无明显差异。疗程结束后近期观察3个月,其HbeAg、HBVDNA阴转率及复发率,在联合组分别为46.2％、45.2％、6.7％,单用组分别为22.2％、28.6％、11.7％,护肝组分别为3.8％、3.2％、25.9％,有显著差异。结论 小剂量干扰素联合阿昔洛韦治疗慢性乙肝具有与常规剂量干扰素同等的治疗效果,且副作用轻,治疗费用低。

Objective To compare the effects of therapeutic low dosage IFN accompanied by Acyclovir, IFN alone and common liver- protection medicines on patients with chronic hepatitis B.Methods The selected 84cases of patients were randomly divided into three groups.The first group of 32 cases of patients was trated with IFN 1mu plus A-cyclovir 0.75; the second group of 21 cases of patients was treated with IFN 3mu alone; and the third group of 31 cases of patients was treated with injectio ganyanling 4ml.For all the three groups, the treatment processes are three months long during which the changes of clinical index, ALT and virus replication were observed.Results Hepatitis symptoms of all of the patients in three groups were released or removed, liver functions were improved and there were no significant timing differences for ALT returning to its normal level in 2 months after after treatment.3 months of continual observation after treatment discovered that the HbeAG, inhibition rates of HBV DNA and relapse rates were 46.2% , 45.2% and 6.7% respectively for the first group; 22.2%, 28.6% and 11.7% for the second group; 3.8%, 3.2% and 25.9% for the third group. Conclusion Low dosage IFN accompanied by Acyclovir has the same treatment effect on chronic hepatitis B with that of the routine dosage IFN while less side effect and lower cost.