慢性阻塞性肺疾病急性发作期血清白介素-8·超氧化物歧化酶和丙二醛的测定

Determination and clinical significance of serum interleukin-8,superoxide dismutase and malondialdehyde in the patients with chronic obsturctive pulmonary disease in acute episode stage

目的 :观察血清白介素 -8(IL -8)、超氧化物歧化酶 (SOD)和丙二醛 (MDA)在慢性阻塞性肺疾病 (COPD)急性加重期和缓解期的变化并评价其临床意义。方法 :COPD急性加重期病人 2 3例列为观察组 ,选择非呼吸道疾病的同期住院患者 3 0例为对照组。两组年龄、性别无显著差异。分别观察两组病人的IL -8、SOD和MDA ,并进行分析对比。结果 :观察组在急性发作期或缓解期IL -8、MDA与对照组相比均有显著增高 ,SOD降低 ,经治疗IL -8和MDA有显著下降 ,SOD增高。与治疗前比较有显著性差异 (P <0 .0 1,P <0 0 5 )。结论 :测定血清IL -8时 ,结合SOD、MDA测定可有助于反映COPD病情或用于疗效评定。

Objective To observe the change of serum interleukin-8(IL-8),superoxide dismutase (SOD)and malondialdehyde (MDA)in patients with chronic obstructive pulmonary disease(COPD)in acute episode stage and remission stage,and to evaluate its clinical significance.Methods Twenty-three patients with COPD in acute episode stage were treated in our hospital and controlled with other 30 patients admitted in our hospital at the same time for other diseases but not respiratory system diseases.There was on significant difference in age and sex between two groups.All the patients in these two groups were observed and compared IL-8,SOD and MDA changes.Results IL-8 and MDA in former group were greatly increased and SOD was decreased both in acute episode stage and remission stage compared with control group.IL-8 and MDA were obviously lower after treatment ( P<0.01,P <0.05).SOD was increased.Conclusions To combine the determination of serum IL-8 with SOD and MDA could help to reflect the state of illness and to judge the therapeutic effect. [