摘要
Although gonadotropin releasing hormone (GnRH), GnRH like molecule, and GnRH receptor (GnRH R) have been reported to exist in several tissues other than brain or anterior pituitary, there are no reports concerning GnRH or GnRH R gene expression in a normal pancreatic gland. In order to define the production of GnRH as well as GnRH R in the pancreatic gland, we examined their gene expression in various developmental stages of rat pancreas using the reverse transcriptase polymerase chain reaction (RT PCR). GnRH mRNA transcripts were found in pancreas of male and female rats at different ages, expressing at about the same level, whereas GnRH R mRNA transcripts could not be detected in any rat pancreatic gland samples. These results suggest a possible biological role of GnRH in rodent pancreas.
Although gonadotropin releasing hormone (GnRH), GnRH like molecule, and GnRH receptor (GnRH R) have been reported to exist in several tissues other than brain or anterior pituitary, there are no reports concerning GnRH or GnRH R gene expression in a normal pancreatic gland. In order to define the production of GnRH as well as GnRH R in the pancreatic gland, we examined their gene expression in various developmental stages of rat pancreas using the reverse transcriptase polymerase chain reaction (RT PCR). GnRH mRNA transcripts were found in pancreas of male and female rats at different ages, expressing at about the same level, whereas GnRH R mRNA transcripts could not be detected in any rat pancreatic gland samples. These results suggest a possible biological role of GnRH in rodent pancreas.
基金
the National Natural Sciences Foundationof China(No. 39770 388)
