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Molecular mechanisms of TRAIL-induced apoptosis of cancer cells 被引量：2

Molecular mechanisms of TRAIL-induced apoptosis of cancer cells
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摘要 Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) is a recently identified member of the tumor necrosis factor (TNF) family[1]. Numerous studies indicate that TRAIL can induce apoptosis of cancer cells but not of normal cells, pointing to the possibility of developing TRAIL into a cancer drug[2-4]. This review will summary the molecular mechanisms of TRAIL-induced apoptosis and discuss the questions to be resolved in this field.
作者 Lianyun Li Hongbing Shu
机构地区 Peking Univ
出处 《Chinese Science Bulletin》 SCIE EI CAS 2001年第9期707-709,共3页
基金 This work was supported by the National Natural Science Foundation of China (Grant No. 39925016) the National Key Basic Science Program (Grant No. G19990539) and Peking University.
关键词 TRAIL CELL NF In Molecular mechanisms of TRAIL-induced apoptosis of cancer cells
分类号 R730.2 [医药卫生—肿瘤]
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参考文献24

  • 1M. A. Degli-Esposti,W. C. Dougall,P. J. Smolak.The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an imcomplete death domain. Immunity . 1997
  • 2FC Kischkel,DA Lawrence,A Chuntharapai,P Schow,KJ Kim.Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity . 2000
  • 3Wiley SR,Schooley K,Smolak PJ,et al.Identification of a newmember of the TNF family that induces apoptosis. Immunity . 1995
  • 4Gura,T,How TRAIL kills cancer cells.but not normal cells. Science . 1997
  • 5MR Sprick,MA Weigand,E Rieser,CT Rauch,P Juo.FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity . 2000
  • 6P. Schneider,M. Thome,K. Burns.TRAIL receptors 1(DR4) and 2(DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity . 1997
  • 7P. M. Chaudhary,M. Eby,A. Jasmin.Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway. Immunity . 1997
  • 8Degli Esposti MA,Smolak PJ,Walczak H,et al.Cloning and characterization of TRAIL-R3 , a novel member of the emerging TRAIL receptor family. The Journal of Experimental Medicine . 1997
  • 9EmeryJG,McDonnellP,BurkeMB,etal.Osteoprotegerinisare ceptorforthecytotoxicligandTRAIL. Journal of Biochemistry . 1998
  • 10W. H. Hu,H. Johnson,H. B. Shu.Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. Journal of Biological Chemistry . 1999

同被引文献18

  • 1祝瑾,李宁川,程宏.TRAIL诱导白血病细胞凋亡的分子机制研究[J].实用临床医药杂志,2004,8(3):36-40. 被引量：8
  • 2Fiona C. KIMBERLEY,Gavin R. SCREATON.Following a TRAIL: Update on a ligand and its five receptors[J].Cell Research,2004,14(5):359-372. 被引量：27
  • 3赵湜,王红祥,毛红,邹萍.肿瘤坏死因子相关凋亡诱导配体联合三氧化二砷对急性髓系白血病细胞凋亡的影响[J].中华血液学杂志,2005,26(1):51-52. 被引量：6
  • 4Waiant H.TNF-Related Apoptosis Inducing Ligang (TRAIL) and its Receptors in Tumor Surveillance[J].Apoptosis,2002,7 (5) :449-459.
  • 5Youngleem Kim Y L,Seol D W.TRAIL,a Mighty Apoptosis Inducer[J].Mol.Cells,2003,15(3) :283-293.
  • 6Kim K,Fisher M J,Xu S Q,et al.Molecular Determinants of Response to TRAIL in Killing of Normal and Cancer Cells[J].Clin Cancer Res,2000,6(2):335-346.
  • 7Wiley S R,Schooley K,Smolak P J,et al.Identification and Characterization of a New Member of the TNF Family that Induces Apoptosis[J].Immunity,1995,3(6) :673-682.
  • 8Yagita H,Takeda K,Hayakawa Y,et al.TRAIL and its Receptors as Targets for Cancer Therapy[J].Cancer Sci,2004,95(10) :777-783.
  • 9Walczak H,Miller R E,Ariail K,et al.Tumoricidal Activity of Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Vivo[J].Nat Med,1999,5:157-163.
  • 10Shankar S,Srivastava R K.Enhancement of Therapeutic Potential of TRAIL by Cancer Chemotherapy and Irradiation:Mechanisms and Clinical Implications[J].Drug Resist Updat,2004,7:139- 156.

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Chinese Science Bulletin
2001年 第9期

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