期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Survivin、Bcl-2在I期NSCLC中的表达及其临床意义 被引量：1

Expression and Significance of Survivin and Bcl-2 in Stage I Non-small Lung Cancer
下载PDF
导出
摘要 目的手术后I期非小细胞肺癌的预后情况与众多因素有关,凋亡相关基因在肿瘤的发生发展过程中发挥重要的作用。本研究通过检测凋亡相关基因Survivin及Bcl-2在I期非小细胞肺癌中的表达情况,探讨其在I期非小细胞肺癌的临床意义和预后价值。方法利用免疫组化学技术检测85例I期非小细胞肺癌(NSCLC)及20例肺良性肺组织中Survivin和Bcl-2的表达,统计分析这两者在I期非小细胞肺癌的作用。结果85例I期非小细胞肺癌组织中Survivin和Bcl-2的表达率分别为64.7%(55/85)和52.9%(45/85)与正常肺组织中的表达差异显著(P<0.05);多因素分析显示PTNM分期与Survivin蛋白的阳性表达是I期非小细胞肺癌患者独立预后因素(P<0.01),Survivin、Bcl-2蛋白的表达与临床、病理各因数无相关。结论在I期非小细胞肺癌中,凋亡相关基因Survivin及Bcl-2可能对肿瘤的发展与预后产生一定的作用与影响;PTNM分期与Sur-vivin蛋白的阳性表达是此Ⅰ期非小细胞肺癌术后患者的独立预后因素。 Objective To investigate the expression of the representative apoptosis-related oncogene survivin and Bcl-2 in stage I non-small cell lung cancer and its clinical value. Methods The expression of survivin and Bcl-2 was detected by using Labelled Streptavidin Biotin immunohistochemistry assay in 85 NSCLC stage I surgical specimens and 20 benign disease specimens. Results The positive rates of survivin and Bcl-2 were 64. 7% （55/85） and 52.9% （45/85）, respectively, there was significant difference between tumour and non-tumour （P 〈 0.05）. PTNM stage and positive expression of survivin were independent prognostic factors of stage I NSCLC . Conclusion In stage I NSCLC, apoptosis-related oncogene may be important to the occurrence and development of lung cancer; PTNM stage and positive expression of survivin are independent prognostic factors.
作者 廖伟 汪道峰 马刚
机构地区 华南肿瘤学重点实验室 中山大学附属肿瘤医院ICU
出处 《咸宁学院学报（医学版）》 2009年第1期13-16,共4页 Journal of Xianning Univarsity(medical Sciences)
关键词 肺肿瘤 癌 非小细胞性 SURVIVIN BCL-2 Lung neoplasms Cancer Non-small cell Survivin Bcl-2
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1王梅,王冰,王晓丽,李明众,莫立平.Survivin在宫颈上皮内瘤样变及宫颈癌中表达的初步研究[J].肿瘤研究与临床,2001,13(4):229-231. 被引量：12
  • 2Tanaka K, Iwamoto S, Con G, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas[J]. Clin Cancer Res, 2000, 6 (1) : 127
  • 3Sarela AI, Macadam RC, Farmery SM, et al. Expression of the antiapoptosis gene, survivin, predicts death from recurrent eolorectal carcinoma [ J ]. Gut, 2000, 46 (5) : 645.
  • 4Monica Falleni, Caterina Pellegrini, 1 Antonio Marchetti, et al. survivin gene expression in early stage non-small cell lung cancer [ J ]. Journal of Pathology, 2003,200 (5) : 620
  • 5Cagini L, Monacelli M, Giustozzi G, et al. Biological prognostic factors for early stage completely resected nonsmall cell lung cancer [ J ]. J Surg Oncol, 2000,74 ( 1 ) : 53
  • 6朱志华,杨弘,傅剑华,胡祎,马芸,吴秋良,戎铁华,汪道峰.Survivin蛋白在早期非小细胞肺癌中的表达及其与预后的关系[J].癌症,2007,26(11):1268-1271. 被引量：7

二级参考文献17

  • 1汪道峰,曾灿光,林勇斌,侯景辉,朱志华.凋亡相关基因在Ⅰ、Ⅱ期非小细胞肺癌组织中的表达及临床意义[J].癌症,2006,25(3):359-362. 被引量：7
  • 2Ambrosini G, Adida C, Ahieri D C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [J]. Nat Med, 1997,3(8) :917-921.
  • 3Monzo M, Rosell R, Felip E, et al. A novel anti-apoptosis gene: re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers [J]. J Clin Oncol, 1999,17(7) :2100-2104.
  • 4Kohmura T, Hasegawa Y, Matsuura H, et al. Clinical analysis of multiple primary malignancies of the hypopharynx and esophagus [J]. Am J Otolaryngol, 2001,22(2): 107-110.
  • 5Ikehara M, Oshita F, Kameda Y, et al. Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung [J]. Oncol Rep, 2002,9(4) : 835-883.
  • 6Shinohara E T, Gonzalez A, Massion P P, et al. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma [J]. Cancer, 2005,103 (8) : 1685-1692.
  • 7Lu B, Gonzalez A, Massion P P, et al. Nuclear survivin as a biomarker for non-small-cell lung cancer [J]. Br J Cancer, 2004,91 (3) : 537-540.
  • 8Falleni M, Pellegrini C, Marchetti A, et al. Survivin gene expression in early-stage non-small cell lung cancer [J]. J Pathol, 2003,200( 5 ) : 620-626.
  • 9Adida C,Crotty P L,McGrath J,et al.Developmentally regulated expression of the novel cancer anti -apoptosis gene survivin in human and mouse differentiation[].American Journal of Pathology.1998
  • 10Adida C,Berrebi D,Peuchmaur M,et al.Anti -apoptosis gene,survivin, and prognosis of neuroblastoma[].The Lancet.1998

共引文献17

同被引文献25

  • 1Manegold C, Thatcher N. Survival improvement in thoracic cancer: progress from the last decade and beyond. Lung Cancer, 2007,57 Suppl 2 : S3-S5.
  • 2Altieri DC. Survivin and IAP proteins in cell death mechanisms. Biochem J, 2010,430: 199-205.
  • 3Chanvorachote P, Pongrakhananon V, Wannachaiyasit S, et al. Curcumin sensitizes lung cancer cells to cisplatin- induced apoptosis through superoxide anion-mediated Bcl-2 degradation. Cancer Invest, 2009,27 : 624 635.
  • 4Altieri DC. Survivin, cancer networks and pathway-directed drug diseovery. Nat Rev Cancer,2008,8:61-70.
  • 5Nienaber CA, yon Kodolitsch Y, Nicolas V, et al. The diagnosis of thoracic aortic dissection by noninvasive imaging procedures. N Engl J Med, 1993,328: 1-9.
  • 6Adida C, Crotty PL, MeGrath J, et al. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol, 1998,152:43-49.
  • 7Porebska I, Sobafiska E, Kosacka M, et al. Apoptotic regulators:P53 and survivin expression in non-small cell lung cancer. Cancer Genomics Proteomics, 2010,7: 331-335.
  • 8Ohashi H, Takagi H, Oh H, et al. Phosphatidylinositol 3 kinase/Akt regulates angiotensin Ⅱ induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity. Circ Res,2004,94:785-793.
  • 9Gao W, Mady HH, Melhem MF, et al. Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients. Mol Careinog, 2009,48 : 633-641.
  • 10Grossman D, Kim PJ, Schechner JS, et al. Inhibition of melanoma tumor growth in vivo by survivin targeting. Proc Natl Aead Sci U S A,2001,98:635-640.

引证文献1

二级引证文献2

咸宁学院学报（医学版）
2009年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部