参麦对硬膜外麻醉病人血流动力学的影响

Influences of Shenmai on Hemorheology in Epidural Anesthetized Patients

目的 :研究参麦对硬膜外麻醉病人血流动力学的影响。方法 :硬膜外麻醉择期手术病人 40例 ,随机分为参麦组和对照组各 2 0例 ,参麦组病人在麻醉时静脉注射参麦注射液 5 0ml。全部病人在麻醉前后用LBY血流动力测试仪进行血流动力学指标如全血粘度、血浆粘度值、血沉、红细胞比容、全血还原粘度、血沉方程K值、全血相对粘度、红细胞变形指数TK检测 ,比较参麦用药前后及参麦组和对照组各项指标的变化。结果 :硬膜外麻醉病人用参麦后不同切变的全血粘度、红细胞比容、全血还原粘度、血沉方程K值、全血高切相对粘度及红细胞变形指数TK明显降低 (P <0 .0 1) ,血浆粘度值、全血低切还原粘度也有所降低 ( 0 .0 1<P <0 .0 5 )。两组麻醉前后血流变主要指标的差值有显著意义 (P <0 .0 5 )。结论 :参麦对手术病人血流动力学有明显影响。

Objective: To investigate the effect of Shenmai injection liquid on hemorheological indexes in surgery patients by epidural anesthesia.Methods:Forty patients were divided randomly into Shenmai group (20 patients) and control group (20 patients). The patients in Shenmai group were given intravenously an injection of Shenmai liquid 50 ml. Whole blood viscosity (high,middle low shear rates),plasma viscosity, erythrocyte sedimentation rate (ESR),hematocrit(Hct),reduced whole blood viscosity, K titer in the ESR equation,whole blood relative viscosity and RBC deformability indexes were measured before and 0.5h and 1h after epidural anesthesia in all patients.Results:whole blood viscosity (high,middle; low shear rates),hematocrit (Hct),reduced whole blood viscosity,K titer in the ESR equation, whole blood relative viscosity (high shear rates)and RBC deformability were significantly lower than those after the injecton of ShenMai.A decrease in most hemorheological indexes in two groups was significant before and after epidural anesthesia.Conclusion: Shenmai injection liquid could markedly decrease the blood viscosity in surgery patient by epidural anesthesia.