急性心肌梗死患者血脂与前列环素、血栓素相关性的研究

The relationship between lipid metobolism and PG system with AMI patients

目的 本试验观察了140例正常人及80例急性心肌梗死(AMI)患者的血脂水平和PGI2(前列环素)、TXA2(血栓素)的稳定代谢产物6-Keto-PGFla、TXB2及T/P水平的变化,并对AMI患者中血脂各项和6-Keto-PGFla、TXB2及T/P进行相关分析,结果显示:AMI患者的TC、TG、LDL、APOB、6-Keto-PGFla、TXB2水平高于正常人,而HDL、APOAI、T/P水平低于正常人(P<0.05),单因素相关分析表明:AMI患者的6-Keto-PGFla与TC、LDL显著相关(P<0.05)、6-Keto-PGFla、TXB2与LP(a)显著相关(P<0.05)。提示:AMI患者的血脂、PGI2、TXB2之间有一定的相关关系,表明冠心病、急性心梗的发病机制的两大学说——血脂沉积学说和血小板聚集血栓形成学说之间可能有些内在联系。

Objective Change of plasma levels of lipid, lipoproteins, anpoliprotein and 6-Keto-PGFla, TXB2, the state metabolites of prostacyclin(PGI2), throm-boxan (TXA2), were stutied in 140 healthy subjects and 80 patients with acute myocardial infarction (AMI). We also analysed the correlations of above indexes of the patients with AMI. The main results were showed as below: the level of plasma total cholestreo (TC), triacylglycerol (TG), low density lipoprotein (LDL), apolipoprotein B(apoB), lipoprotein (a) [La(a)], 6-Keto-PGFla, TXB2 were slightly increased in the AMI group. But the high density lipoprotein (HDL), apolipoprotein AI (apoAI), T/Pratio is lower than the controls (P<0.05). The corrolatic analys shows: in the patients with AMI, the level or PGI2 was related with TC, LDL, LP(a), and the level of TXA2 was connected with the level of LP(a) (P < 0. 05). Conclusion They have some relationship between lipid metobolism and PG system for AMI patients.