血清一氧化氮水平测定在皮肌炎中的临床意义

The measurement of the level of nitric oxide in serum and its clinical significance in patients with dermatomyositis

目的研究血清一氧化氮浓度在皮肌炎发生发展中的作用及临床意义。方法应用化学比色法对３８例不同病期皮肌炎患者进行一氧化氮浓度的测定。结果皮肌炎患者活动期血清一氧化氮水平高于正常对照组，差异有显著性（Ｐ＜０．０５）。皮肌炎缓解期血清一氧化氮水平与正常对照组比较差异无显著性（Ｐ＞０．０５）。结论一氧化氮可能参与皮肌炎的炎症反应。一氧化氮测定对了解病情程度，评价疗效及探讨皮肌炎的发病机理有一定价值。

Objective To study the role and clinical significance concentration of nitric oxide in the development of dermatomyositis. MethodsBZ]The concentration of nitric oxide in serum was measured by chemocolorimetry in 38 patients with dermatomyositis. Results The concentration of nitric oxide in serum was (6.310.45) molL-1 in patients with dermatomyositis at active stage higher than (5.870.38) molL-1 in normal control group (P<0.05). The concentration of nitric oxide in dermatomyositis at recovery stage was not changed in comparison with normal control group (P>0.05). Conclusion It was suggested that nitric oxide may participate inflammatory reaction in patients with dermatomyositis. Assay of nitric oxide is worthy in estimating severity, therapeutic evaluation and pathogenesis in patients with dermatomyositis.