肝炎病人中庚型肝炎病毒感染的研究

Researches on infection of hepatitis G virus in patients with hepatitis

目的探讨庚型肝炎病毒（ＨＧＶ）的流行情况及ＨＧＶ感染后的临床特征。方法运用ＲＴ－ＰＣＲ法检测２１０例肝炎患者血清ＨＧＶＲＮＡ。结果ＨＧＶ感染率为９．５％，其中ＨＧＶ与ＨＢＶ、ＨＣＶ的合并感染率分别为６．７％、１５％，非甲－戊型肝炎中检出３例１０％。将ＨＧＶ与ＨＢＶ、ＨＣＶ混合感染与ＨＢＶ、ＨＣＶ单纯感染的肝功能损害程度进行对比分析，结果显示二组无显著性差异。结论ＨＧＶ的致病力较弱，可能不是非甲－戊型肝炎的主要病因，乙肝、丙肝患者合并ＨＧＶ感染后，病情未见明显加重。

Objective For the purpose of evaluating the prevalence of HGV infection in patients with hepatitis and its clinical characteristics. Method We measured HGV RNA of 210 patients with RTPCR. Result The infection rate of HGV was 9.5%; and coinfections in HGV with HBVHCV were 6.7%15%, respectively. 10% patients with nonAE hepatitis. There were no significant differences in the results of liver function tests between the infections in HBVHCV and HBVHCV coinfected with HCV. These results suggest that the virulence of HGV infection appears to be mild. Conclusion HGV is unlikely to be major etiologic agent for nonAE hepatitis. HGV coninfection does not worsen patient's condition with hepatitis B and C.