冶炼烟尘对工人生物学监测指标的影响

Effects of exposure to smeltery fumes on biological monitoring indexes in metals recovery smeltery workers

目的 探讨接触金属冶炼烟尘对废金属冶炼工生物学监测指标的影响。方法 以３０ 名冶炼工为接触组，分别测定其尿和唾液中Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶（ＮＡＧ）活性和尿中δ－ＡＬＡ和尿碱性磷酸酶（ＡＫＰ）含量作为金属烟雾对肾损害的生物学监护指标；另以５０ 名医大学生和２０名慢性肾病患者分别作为正常对照和肾损害的阳性对照组。结果 接触组尿和唾液中的ＮＡＧ 活性显著高于正常，但均显著低于阳性对照组。接触组尿中δ－ＡＬＡ和ＡＫＰ含量均显著高于正常对照组（Ｐ＜ ０．０１），且接触组尿ＮＡＧ活性和尿中ＡＫＰ间呈显著正相关（ ｒ＝ ０．７１３，Ｐ＜ ０．０５）。结论尿中δ－ＡＬＡ 和ＡＫＰ及唾液和尿中ＮＡＧ酶活性测定。

Objective Urine and salive N acetyl β D glucosaminidase (NAG) and urine δ aminolevuline acid (ALA) and urine AKP were observed in smeltery workers. And their values for diagnosis of early injury were studied. Methods 30 smelters were studied as an exposed group. The control groups consisted of control A (50 medical university students) and control B (20 chronical nephritides patients as positive control group). Results The activity of NAG in urine and salive of exposed group were significantly higher than those in control A and lower than in control B. Conclusions NAG, δ ALA and AKP in urine and NAG in urine and salive may be used as a group of biological monitoring indexes for smelters. Abstract Objective Urine and salive N acetyl β D glucosaminidase (NAG) and urine δ aminolevuline acid (ALA) and urine AKP were observed in smeltery workers. And their values for diagnosis of early injury were studied. Methods 30 smelters were studied as an exposed group. The control groups consisted of control A (50 medical university students) and control B (20 chronical nephritides patients as positive control group). Results The activity of NAG in urine and salive of exposed group were significantly higher than those in control A and lower than in control B. Conclusions NAG, δ ALA and AKP in urine and NAG in urine and salive may be used as a group of biological monitoring indexes for smelters.