期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Effects of PKCa antisense RNA on human breast cancer cell proliferation and expression of cyclinD1 and CDK4

Effects of PKCαantisense RNA on human breast cancer cell proliferation and expression of cyclinDl and CDK4
原文传递
导出
摘要 The role of PKCα in human breast cancer cell proliferation and expression of cyclinD1 and CDK4 has been investigated using inhibition of PKCα expression by its antisense RNA. When PKCα expression was inhibited the rate of cell proliferation decreased apparently and the levels of cyclinD1 and CDK4 mRNA were lower than the control. The results showed that PKCα, a key member of signal transduction system, played an important role in human breast cancer cell proliferation and had a close relationship with expression of cyclinD1 and CDK4 which control start of cell cycle. The role of PKCα in human breast cancer cell proliferation and expression of cyclinD1 and CDK4 has been investigated using inhibition of PKCα expression by its antisense RNA. When PKCα expression was inhibited the rate of cell proliferation decreased apparently and the levels of cyclinD1 and CDK4 mRNA were lower than the control. The results showed that PKCα, a key member of signal transduction system, played an important role in human breast cancer cell proliferation and had a close relationship with expression of cyclinD1 and CDK4 which control start of cell cycle.
作者 SANG Jianli WANG YongchaoLaboratory of Cell Biology , Department of Biology, Beijing Normal University, Beijing 100875 , China
出处 《Chinese Science Bulletin》 SCIE EI CAS 1999年第12期1110-1114,共5页
关键词 BREAST cancer PKCΑ cell proliferation CYCLIND1 CDK4. breast cancer, PKCα, cell proliferation, cyclinD1, CDK4.
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Hahnel R,Gschwendi M.The interaction between protein kinase C and estrogens. International Journal of Oncology . 1995
  • 2NISHIZUKA,Y.Studies and perspectives of protein kinase C. Science . 1986
  • 3K Keyomarsi,AB Pardee.Redundant cyclin overexpression and gene amplification in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America . 1993
  • 4Grana X,Reddy EP.Cell cycle control in mam -malian cells:roll of cyclins,cyclin- dependentkinases(CDKs) ,growth suppressor genes and cyclin- depen-dent kinase inhibitors. Oncegene . 1995
  • 5C O’Brian,VG Vogel,SE Singletary,NE Ward.Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Research . 1989
  • 6Ways DK,Kukoly CA,deVente J,et al.MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibited altered expression of other protein kinase C isoforms and display a aggressive neoplastic phenotype. The Journal of Clinical Investigation . 1995
  • 7Alvaro V,Touraine P,Vozari RR,et al.Protein kinase C activity and expression in normal and adenomatous human pituitaries. International Journal of Cancer . 1992
  • 8Prevostel, C,Alvaro, V,De Boisivilliers, F. et al.The natural protein kinase Ca mutant is present in human thyroid neoplasms. Oncegene . 1995
  • 9Sutherland, R. L,Hamilton, J. A,Sweeney, K. J. E. et al.Expression and regulation of cyclin genes in breast cancer. Acta Oncologica . 1995
  • 10Horrington, E. O,Loffler, J,Nelson, P. R. et al.Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδin capillary endothelial cells. Journal of Biological Chemistry . 1997
Chinese Science Bulletin
1999年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部