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Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser/Thr protein kinase

Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser/Thr protein kinase
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摘要 A novel full-length cDNA encoding a putative serine/threonine kinase has been isolated from a human testis cDNA library. A nucleotide sequence of 1 225 bp length has been determined containing an open reading frame of 1 044 nucleotides (encoding 348 amino acids). In view of its degree of homology to members of the Ser/Thr protein kinase family and the closest relationship to Mus musculus STK-1, the predicted product was designated by the name of HUMSTK-1. Its mRNA is present in large amounts in thymus, and small amounts in testis,small intestine and colon. A novel full-length cDNA encoding a putative serine/threonine kinase has been isolated from a human testis cDNA library. A nucleotide sequence of 1225 bp length has been determined containing an open reading frame of 1 044 nucleotides (encoding 348 amino acids). In view of its degree of homology to members of the Ser/Thr protein kinase family and the closest relationship toMus musculus STK-1, the predicted product was designated by the name of HUMSTK-1. Its mRNA is present in large amounts in thymus, and small amounts in testis, small intestine and colon.
机构地区 Fudan Univ
出处 《Chinese Science Bulletin》 SCIE EI CAS 1999年第9期778-783,共6页
关键词 serine/threonine KINASE CDNA cell cycle homology. serine/threnine kinase cDNA cell cycle homology
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