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Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves 被引量:5

Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves
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摘要 Calf thymus DNA was exposed to low-energy heavy ions (N+) and 60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential type, the effect curve produced by N+ ion is of 'saddle type'. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level. Calf thymus DNA was exposed to low-energy heavy ions (N+) and60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential type, the effect curve produced by N+ ion is of “saddle type”. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level.
机构地区 Wuhan Univ
出处 《Chinese Science Bulletin》 SCIE EI CAS 1999年第8期711-715,共5页
关键词 ion implantation γ-rays 'saddle types' CURVE DNA SINGLE-STRAND BREAKS CURVE fitting. ion implantation γ-rays “saddle types” curve DNA single-strand breaks curve fitting
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