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Research advances in genetic engineering of plantibody

Research advances in genetic engineering of plantibody
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摘要 The combination of engineering antibody and plant biotechnology creates the plantibody. It has been reported that the engineering antibodies expressed in plant, no matter whether they are intact or small-molecular antibodies, keep their antigen-binding specificity, which means they are functional.This trait makes plantibody notable. Now the researches are focused mainly on the following three aspects: ( ⅰ ) Therapeutic antibody in clinic. It is expected to offer the opportunity of large-scale antibody production in agriculture systems, for the purpose of decreasing the cost greatly. Moreover, the property of multiple sexual hybridization between plants can be used to produce bi-or multi-functional antibodies and create new antibody medicines. (ⅱ) Plant physiology. Engineering antibodies against plant hormones or some active materials can block their activities in plant, so the trait of plantibody could be used to study the growth and development of plant. ( ⅲ ) Plant disease-resistance. The gene of The combination of engineering antibody and plant biotechnology creates the plantibody. It has been reported that the engineering antibodies expressed in plant, no matter whether they are intact or small-molecular antibodies, keep their antigen-binding specificity, which means they are functional. This trait makes plantibody notable. Now the researches are focused mainly on the following three aspects: (i) Therapeutic antibody in clinic. It is expected to offer the opportunity of large-scale antibody procluction in agriculture systems, for the purpose of decreasing the cost greatly. Moreover, the property of multiple sexual hybridization between plants can be used to produce bior multi-functional antibodies and create new antibody medicines. (ii) Plant physiology. Engineering antibodies against plant hormones or some active materials can block their activities in plant, so the trait of plantibody could be used to study the growth and development of plant. (iii) Plant disease-resistance. The gene of antibody against plant virus can be transferred into plant to defend the intrusion of virus in order to cure the disease.
机构地区 Chinese Acad Sci
出处 《Chinese Science Bulletin》 SCIE EI CAS 1999年第5期390-397,共8页
关键词 ANTIBODY GENE TRANSGENIC PLANT GENE EXPRESSION plantibody. antibody gene transgenic plant gene expression plantibody
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