Relationship between the analgesic effect of electroacupuncture and CCK-8 content in spinal perfusate in rats 被引量：1

Relationship between the analgesic effect of electroacupuncture and CCK-8 content in spinal perfusate in rats

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摘要 There exists significant individual variation in electroacupuncture (EA) induced analgesia.Rats may be classified as high- and low-responders according to their response to EA analgesia. The content of cholecystokinin octapeptide like immunoreactivity (CCK-8-ir) in the spinal perfusate of highresponder (HR) and low-responder (LR) rats was measured with radioimmunoassay. The result showed that the CCK-8-ir content in LR rats was significantly lower than that in HR rats. There exists a negative correlation between the EA effect and the CCK-8-ir content during EA stimulation. It is concluded that the spinal release of CCK-8 may be one of the key factors determining the effect of EA analgesia. There exists significant individual variation in electroacupuncture (EA) induced analgesia. Rats may be classified as high- and lowresponders according to their response to EA analgesia. The content of cholecystokinin octapeptide like immunoreactivity (CCK-8-ir) in the spinal perfusate of highresponder (HR) and low-responder (LR) rats was measured with radioimmunoassay. The result showed that the CCK-8-ir content in LR rats was significantly lower than that in HR rats. There exists a negative correlation between the EA effect and the CCK-8-ir content during EA stimulation. It is concluded that the spinal release of CCK-8 may be one of the key factors determining the effect of EA analgesia.

作者 Suxing Liu Fei Luo Shang Shen Yingxin Yu Jisheng Han

机构地区 Baotou Med Univ Beijing Med Univ

出处《Chinese Science Bulletin》 SCIE EI CAS 1999年第3期240-243,共4页

关键词 ELECTROACUPUNCTURE ANALGESIA individual variation CHOLECYSTOKININ OCTAPEPTIDE SPINAL perfusate. electroacupuncture analgesia individual variation cholecystokinin octapeptide spinal perfosate

分类号 R246.2 [医药卫生—针灸推拿学]

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Chinese Science Bulletin

1999年第3期

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