血清一氧化氮和肿瘤坏死因子α与肝硬化并发症的关系

NITRIC OXIDE AND ITS RELATIONSHIP WITH COMPLICATIONS IN LIVER CIRRHOSIS

目的 探讨血清一氧化氮(NO)、肿瘤坏死因子α(TNFα)与肝硬化并发症的关系。方法 157例肝硬化患者血清标本,分别用化学发光法和酶联免疫反应法测定NO、TNFα含量。结果 肝硬化有并发症患者血清NO、TNFα含量均高于无并发症患者(P<0.05);治疗前后肝硬化无并发症患者、原发性肝癌患者血清NO、TNFα含量无明显变化(P>0.05);上消化道出血、肝肾综合征、肝性脑病、自发性细菌性腹膜炎时则变化明显(P<0.05)。结论 NO、TNFα在肝硬化出现并发症时升高,好转则下降。

Objective To study the relationship between nitric oxide (NO),tumor necrosis factor-α(TNFα) and complications in liver cirrhosis (LC). Methods Serum NO,TNFα levels were detected with chemoluminescence method and ELISA in 157 LC patients. Results Serum NO.TNFα levels in LC patients without complications were lower than that in with complications. With relief of complications, the serum NO,TNFα levels decreased significantly ( P <0.05). Conclusion The results suggest that serum NO and TNFα might be a useful markers for complications existence in LC patients.