慢性乙型肝炎和肝硬化患者血清可溶性细胞间粘附分子-1的检测

THE SERUM LEVEL OF SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 IN PATIENTS WITH CHRONIC HEPATITIS B AND LIVER CIRRHOSIS

目的 探讨可溶性细胞间粘附分子-1(sICAM-1)在慢性乙型肝炎和肝硬化中的临床意义。方法 应用酶联免疫吸附法检测56例慢性乙型肝炎和18例肝硬化患者血清sICAM-1水平,并同时检测肝功能和T细胞亚群。结果 慢性乙型肝炎和肝硬化患者血清sICAM-1水平明显高于正常人(P<0.01/0.05),且随着肝细胞损伤程度的加重而升高,与T细胞亚群无相关性。结论 血清sICAM-1水平可反映慢性乙型肝炎患者的肝细胞坏死程度。

Objective To detect the serum level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with chronic hepatits B and with liver cirrhosis. Methods Serum sICAM-1 was detected by ELISA and the liver function and T lymphocyte subsets were detected in 56 patients with chronic hepatitis B and 18 with liver cirrhosis. Results Serum sICAM-1 level in chronic hepatitis B and liver cirrhosis were obviously higher than in normal control ( P >0.01/0.05) and peralleled with the liver function damage, while there was no correlation to CD4+ ,CD8+ or the ratio of CD4+ /CD8+ . Conclusion Serum sICAM-1 levels increase in chronic hepatitis B and in liver cirrhosis.