兰州地区献血员及静脉毒瘾者血清中TT病毒核酸检测及意义

DETECTION OF TRANSFUSION-TRANSMITTED VIRUS (TTV) DNA IN BLOOD DONORS AND INTRAVENOUS DRUG-ABUSERS IN LANZHOU

目的 研究兰州地区献血员及静脉毒瘾者中TT病毒(TTV)的感染状况。方法 利用套式PCR技术检测献血员及静脉毒瘾者血清中TTV DNA。结果 献血员中TTV DNA检出率为7.5％(9/120)。静脉毒瘾者中TTVDNA枪出牢为26.8％(15/56),明显高于献血员组,结论 首次报道兰州地区存在TTV感染。静脉毒瘾者为了TTV感染的高危人群,其致病性较弱。关于TTV的病原学、流行病学、病理学及临床意义等有待进一步探索。

Objective To study the infection rate of transfusion-transmitted virus (TTV) among blooddonors and intravenous drug-abusers in Lanzhou. Methods Nested-PCR(nPCR) was performed for detecting TTV DNA in sera of blood donors and intraverous drug-abusers. Results TTV DNA was detected in 9/120(7. 5% ) sera of blood donors and in 15/56(26.8%) of intraverous drug-abusers. Conclusions The results of this study for the first time confirmed the presence of TTV infection in Lanzhou. The intraverous drug-abusers is the high risk population for TTV infection. Further study should be done to explore TTV's etology,epidemiology, pathology and clinical significance.