华蟾素联合甘利欣治疗急性病毒性肝炎的疗效观察

COMBINATION CINOBU FACINI AND DIAMMONIUM GLYCYRRHIZINATE IN THE TREATMENT OF ACUTE HEPATITIS

目的 观察联合用药对急性乙型肝炎(AH)的治疗效果。方法 46例AH患者随机分为2组,华蟾素联合甘利欣组:华蟾素20ml,静脉滴注、每日一次,甘利欣100mg、每日一次,疗程4周;对照组:单用甘利欣,剂量、用法及疗程同治疗组。疗程结束时检测肝功能、乙型肝炎病毒标志物。结果 华蟾素联合甘利欣与对照组比较,临床总有效率、ALT复常天数有显著差异(P<0.05),HBeAg、HBV DNA阴转率无显著性差异(P>0.05)。结论 华蟾素联合甘利欣对AH具有快速缓解临床症状、护肝降酶及免疫调节作用。

Objective To explore the effect of combination cinobu facini and diammonium glycyrrhizinate in the treatment of acute hepatitis (AH). Methods 46cases diagnosed as AH were randomly divided into 2 groups,24 patients were treated with combination cinobu facini and diammonium glycyrrhizinate, while 22 with diammonium glycyrrhizinate alone. Results The improvement of clinical symptoms and ALT normality in the cinobu facini group had a significant difference compared with control ( P < 0.05); The HBeAg and HBV DNA loss had no significant difference in the two groups ( P >0.05).Conclusions Combination cinobu facini and diammonium glycyrrhizinate have a good effect on AH in improvement of clinical symptom and the recoveries of ALT.