慢性重型乙型肝炎患者血清可溶性肿瘤坏死因子受体的变化

SERUM LEVELS OF SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR IN PATIENTS WITH CHRONIC SEVERE HEPATITIS

应用酶联免疫吸附试验法测定了32例慢性重型乙型肝炎患者血清可溶性肿瘤坏死因子受体(sTNFR)水平。结果 慢性重型肝炎患者sTNFR水平显著升高,升高程度与总胆红素呈正相关,与凝血酶原活动度呈负相关。伴有感染或肝肾综合征时,sTNFR水平显著高于无感染或无肝肾综合征患者,最终死亡者其水平也显著高于存活者。提示测定慢性重型肝炎患者血清sTNFR水平对判断病情及预测转归有一定的价值。

Serum levels of soluble tumor necrosis factor receptor (sTNFR) were detected with ELISA in 32 patients of chronic severe hepatitis B.The results showed that the serum levels of sTNFR in chronic severe hepatitis B were obviously increased and the sTNFR level was positively correlated with serum total bilirubin concentration, negatively with prothrombin time activity. These results indicate that detection of serum sTNFR in patients with chronic severe hepatitis B is significant for evaluating the clinical severity and for assessing the prognosis of the disease.