T抗原检测在大肠癌早期诊断中的临床意义

Clinical significance of T-antigen assay in the diagnosis of colorectal carcinoma

目的：研究T抗原在大肠癌早期诊断中的临床意义。方法：用半乳糖氧化酶法对大肠癌、大肠息肉在内的128例病人和100例正常对照者的直肠粘液标本T抗原检测。结果：大肠癌病人的T抗原明显高于对照组（P＜0.01），其敏感性为86．3％，特异性为880％。大肠息肉病人T抗原阴性率明显高于对照组（P＜0.01）。结论：T抗原检测是一种早期、特异、灵敏的大肠癌筛选方法，也可试用于癌前病变监测。

Objective: This study was aimed to ascertain the clinical of T-antigen in the progress diagnosis of colorectal carcinomal (CRC), colorectal polyps (CRP). Methods: T-antigen in speci-men of rectal mucus was assayed with galatose oxidase method in 128 victims and 100 health-y in-dividuals, as controls. Results: Disclosed that Disitivity to T-antigen in cases with CRC and CRP,appeared higher than that in controls (P<0. 01) The sensitivity and specificity of the test in CRC proved to be 86. 3% and 88. 0% respectively. Conclusion: It was concluded that T-antigen could be regarded as sacredible means to screen CRC, CRP.