乙肝病毒e抗原系统与HBV DNA的相关性研究

The study of correlation between hepatitis B virus (HBV) e antigen system and HBV DNA

目的：探讨乙肝病毒e抗原系统与HBVDNA的相关性。方法：应用PCR方法检测HBVDNA，ELISA法检测乙肝病毒e抗原系统。结果：HBeAg（＋）的乙肝病人HBVDNA阳性率89．19％，抗HBe（＋）的乙肝病人HBVDNA阳性率60％，HBeAg及抗HBe均阴性的乙肝病人HBVDNA阳性率43．75％，HBeAg（＋）的各型乙肝HBVDNA阳性率无明显差别（P＞0．05），抗HBe（＋）的各型乙肝以慢性中重度乙型肝炎患者HBVDNA检出率最高（75％）。结论：HBVDNA阳性率与乙肝感染类型无关，而与e抗原系统存在状态有关，HBeAg和抗HBe均阴性的患者中也有43．75％的病人有DNA复制。

Objecive: In order to investigate the correlation between the seral change of patients infected with hepatitis B virus (HBV) and viral replication. Mehtods: HBV DNA and e antigen sys-tem were measured in 78 cases infected with HBV with PCR and ELISA respectively. Results:HBV DHB detecting rate was 89. 19% for patients infected. With HBV with HBeAg positive and 6o% for those with anti-HBe positive, but 43. 75% for those with both HBeAg and anti-HBe negative. There was no significant difference in HBV DNA detecting rate among the four HB clini-cal classifications with HBeAg Positive, The HBV DNA detecting rate of COS patients was the highest in the four HB clinical classifications with anti- HBe positive. Conclusions: HBV DNA de-tecting rate wasn't correlated with HB clinical classification, but was correlated with e antigen types HBV DNA replication appeared in 43. 75 % patients with both anti-HBe and HBeAg nega-tive.