雌甾-β-溴乙基醚的合成方法研究

Study on the synthesis of estra-β-bromoecthyl ether

目的：合成雌甾－β－溴乙基醚，并代化反应条件。方法：采用相转移催化和非相转移催化两种反应条件。结果：成功地在两种反应条件下合成了雌－β－溴乙基醚．结论：TBAB催化下，50％氢氧化钠溶液作碱，甲苯中80℃反应为较佳反应条件。

Objective: To synthesize estra-β-bromoethyl ether and to find the best reactive condi-tions. Methods: The methods such as phase transfer catalytic alkylation and homogeneous phase alkylation were used. Results: Estra-β-bromoethyl ether was synthesized successfully under these two conditions. Conclusion: The reaction was performed better in toluene at 80℃ when TBAB was used as catalyzer and 50% NaOH was used as base.