抗凝治疗对急性脑梗塞血浆凝血酶敏感蛋白的影响

Changes of the plasma thrombospondin in the patients with acute cerebral infarction treated with decoagulant

目的：了解阿斯匹林（ASA）、蚓激酶（ePPA）和钙离子拮抗剂对脑梗塞急性期患者治疗前后血小板膜凝血酶敏感蛋白（Thrombospondin，Ts）的影响作用。方法：采用流式细胞术对ASA、ePPA和钙离子拮抗剂治疗前后患者Ts的变化进行检测分析。结果：治疗后患者Ts为3.76±1.72，较治疗前（5．45±3．41）显著降低（P＜0．05）。结论：ASA、ePPA和钙离子拮抗剂可能通过改变Ts含量来发挥抗凝作用。

Objective: To study the thrombospondin (Ts) levels of the acute cerebral infarction(ACI) patients before and after therapy wih ASA, ePPA and calcium antagonist. Methods: PlasmaTs levels of ACI patiets be fore and after treated with ASA, ePPA and calcium antagonist weremeasured by flow cytometry. ResuIts: The level of Ts was 3. 76±1.72 in patients after therapy,while that before therapy was 5- 45 ±3. 41 much higher than former (P＜0.05). Conclusion: ASA,ePPA and calcium antagonist may play a anticoagulating effect by altering the Ts content-