培哚普利对实验性高血压大鼠血管壁肥厚的作用

EFFECTS OF PERINDOPRIL ON VASCULAR HYPERTROPHY IN RAT WITH EXPERIMENTAL HYPERTENSION

用腹主动脉手术缩窄法建立高血压动脉模型。将ＳＤ雄性大鼠３３只随机分成４组：Ａ组，假手术一对照组；Ｂ组，高血压一对照组；Ｃ组，高血压一低剂量培哚普利组（０．１ｍｇ／ｋｇ／ｄ）；Ｄ组，高血压—高剂量培哚普利组（１．５ｍｇ／ｋｇ／ｄ）。药物经灌胃治疗持续４周后通过颈动脉测定平均动脉压（ＭＡＰ），用图像分析法算出主动脉及肠系膜上动脉中膜厚度／管腔内径比值。结论：高剂量和不降低血压的低剂量培哚普利能预防肠系膜上动脉中膜肥厚；高剂量还能显著抑制主动脉中膜肥厚。培哚普利预防血管壁肥厚作用可能是抑制了血管壁中血管紧张素Ⅱ（ＡⅡ），而与血浆中ＡⅡ无关。

The model of hypertensive rat was established by using the method of abdominal aortic constriction. 33 male SD rats were randomly divided into 4 groups: group A (sham operated rats serving as controls), group B (hypertensive rats serving as controls), group C hypertensive rats subjected to low dose perindopril treatment, 0 1 mg/kg -1 /d) and group D (hypertensive rats receiving high dose perindopril treatemnt, 1 5 mg/kg -1 /d). The drug was administered by gavage for 4 weeks. At the end of the treatment, mean arterious pressure (MAP) was measured via catheter in the carotid artery. The ratio of medial thickness to diameter of lumen of aotra and superior mesenteric artery was calculated by morphometry. Our results showed that perindopril, both high dose and low dose, may prevent hypertrophy of the tunica media of superior mesenteric artery. In addition, high dose perindopril may significantly inhibit hypertrophy of aortic media. The above effects of perindopril may be explained by inhibition on tissue angiotension Ⅱ(AⅡ) of vascular wall, but is not related to circulating A Ⅱ(PAⅡ).