摘要
Abstract Sixtynine specimens obtained by surgery were studied by immunohistochemistry using monoclonal antiEcadherin, anticatenin and anti p53 antibodies. the reduced expression of Ecadherin and catenin were 536% and 652% respectively. p53 protein positive staining was 275%. There was significant correlation between Ecadherin and catenin expression, but no relation was found between p53 expression and Ecadherin or catenin expression. catenin reduced expression and p53 overexpression correlated to lymph node metastasis. Submucosa tumors with positive p53 staining and reduced expression of catenin were most likely to have lymph node metastasis, while tumors with p53 negative and catenin presserved expression had no metastasis in either mucosa or submucosa lesions. The results indicate that a combination of catenin and p53 expression with pathological features may be helpful to predict the lymph node metastasis in early gastric cancer.
Abstract Sixtynine specimens obtained by surgery were studied by immunohistochemistry using monoclonal antiEcadherin, anticatenin and anti p53 antibodies. the reduced expression of Ecadherin and catenin were 536% and 652% respectively. p53 protein positive staining was 275%. There was significant correlation between Ecadherin and catenin expression, but no relation was found between p53 expression and Ecadherin or catenin expression. catenin reduced expression and p53 overexpression correlated to lymph node metastasis. Submucosa tumors with positive p53 staining and reduced expression of catenin were most likely to have lymph node metastasis, while tumors with p53 negative and catenin presserved expression had no metastasis in either mucosa or submucosa lesions. The results indicate that a combination of catenin and p53 expression with pathological features may be helpful to predict the lymph node metastasis in early gastric cancer.
