摘要
Intravenous injection of platelet agonists ADP and thrombin induced the accumulation of 111 In labelled platelets within the pulmonary vasculature. Pretreatment with i.v. administration of Dauricine significantly inhibited the platelet accumulation induced by ADP and thrombin in a dose related fashion and this effect lasted less than 40 min. Inhibitor of NO synthase, L NAME, did not change the inhibition of platelet accumulation by Dauricine, but inhibitor of cyclooxygenase, indomethacin, abolished the inhibitory action of Dauricine. These results suggest that Dauricine pretreatment inhibits ADP and thrombin induced platelet aggregation in vivo and its mechanism is related to inhibition of arachidonic acid metabolism.
Intravenous injection of platelet agonists ADP and thrombin induced the accumulation of 111 In labelled platelets within the pulmonary vasculature. Pretreatment with i.v. administration of Dauricine significantly inhibited the platelet accumulation induced by ADP and thrombin in a dose related fashion and this effect lasted less than 40 min. Inhibitor of NO synthase, L NAME, did not change the inhibition of platelet accumulation by Dauricine, but inhibitor of cyclooxygenase, indomethacin, abolished the inhibitory action of Dauricine. These results suggest that Dauricine pretreatment inhibits ADP and thrombin induced platelet aggregation in vivo and its mechanism is related to inhibition of arachidonic acid metabolism.
