摘要
To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with higher blood pressure (HBP) and 150 children matched for age and sex but with normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivity with the tests of oral saline load and furosemide sodium volume depletion and followed for 5 years. The results showed that: ①In children with HBP and positive family history of hypertension (FH +), the plasma insulin level was significantly higher than that in the respective control group (P<0 01);②In children with high plasma insulin level, the percentiles of systolic blood pressure kept high and had a rising tendency during the follow up period; ③In children with sodium sensitivity, the plasma insulin level was higher than that in children with sodium resistance (P<0 01) and the plasma insulin level correlated positively with blood pressure increasing rate of post load (P<0 05). It is suggested that insulin mediated salt and water retention may be a basic pathogenic mechanism in sodium sensitivity, and involved in the development of essential hypertension.
To study the relationship between plasma insulin level, sodium sensitivity and blood pressure, 150 children aged from 10 to 15 years with higher blood pressure (HBP) and 150 children matched for age and sex but with normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivity with the tests of oral saline load and furosemide sodium volume depletion and followed for 5 years. The results showed that: ①In children with HBP and positive family history of hypertension (FH +), the plasma insulin level was significantly higher than that in the respective control group (P<0 01);②In children with high plasma insulin level, the percentiles of systolic blood pressure kept high and had a rising tendency during the follow up period; ③In children with sodium sensitivity, the plasma insulin level was higher than that in children with sodium resistance (P<0 01) and the plasma insulin level correlated positively with blood pressure increasing rate of post load (P<0 05). It is suggested that insulin mediated salt and water retention may be a basic pathogenic mechanism in sodium sensitivity, and involved in the development of essential hypertension.
