急性髓系白血病中MN1基因的研究进展

Advance of Study on MN1 Gene in Acute Myeloid Leukemia——Review

MN1基因编码转录共激活因子,在某些急性髓系白血病(AML)中高表达。MN1在正常核型AML患者中的高表达与预后差和生存时间短相关;在全部inv(16)AML中高表达,其高表达在非M3的AML中被认为与对维甲酸的耐药有关。本文就MN1基因的结构和作用机制、MN1-TEL与急性髓系白血病,MN1与正常核型AML,MN1与inv(16)AML,MN1与维甲酸耐药等作一综述。

The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Overexpression of this gene is associated with all inv （16） AML, retinoic acid-resistance, a worse prognosis as well as a shorter survival in AML patients with a normal karyotype. This article reviews the role of MN1 in acute myeloid leukemia including MN1 gene structure and action mechnism, MN1-TEL and AML with normal karyotype, MN1 and inv（16） AML, MN1 and retinoic ocid-resistance, and so on.