幽门螺杆菌感染的防治研究进展

The research progress in immune protection of Helicobacter pyloyi infection

幽门螺杆菌 ( HP)的发现使慢性胃炎和消化性溃疡发病学和防治学面临着一场革命 ,HP与胃癌关系也十分密切。随着对 HP研究的不断深入 ,从分子水平对 HP的致病机理有了更深的了解。常规的治疗方法如抗生素虽然可以暂时控制 HP的感染 ,但是由于易产生耐药性等许多新的问题 ,因此迫切需要研究新的防治策略。利用 HP抗原与佐剂联合使用或用减毒的沙门氏菌来表达HP的抗原 ,进行口服免疫防治 HP的感染是目前研究的热点。

Helicobacter pyloyi is a widespread human pathogen that colonizes the gastric mucosa and is associated with gastro intestinal illnesses such as chronic gastritis,peptic ulcer,gastric lymphoma and gastric cancer. Current pharmacological therapies are becoming less reliable for the control of H. pyloyi due to the increasing number of antibiotic resistant strains. New vaccination strategies utilizing H. pyloyi antigens combined with adjuvants or delivery of antigens by attenuated salmonella vaccine strains in oral immunization have been successful in protecting mice against H. pyloyi infections.