国产格列美脲药效学试验研究

The Pharmacodynamics Study of Glimepride

为观察国产格列美脲的降血糖作用及对胰岛素分泌的影响,将大鼠、家兔灌服格列美脲2.5mg/kg、5mg/kg、10mg/kg后,通过测血糖、耐糖试验和测血浆胰岛素水平研究格列美脲的作用。结果显示,给药后血糖均明显降低(P<0.01),且药效强于格列本脲;大鼠灌服2.5mg/kg格列美脲已能明显对抗糖负荷引起的血糖升高,随给药剂量升高对抗作用增强;家兔灌服该药上述三种剂量后亦明显对抗糖负荷引起的血糖升高;大鼠和家兔灌服格列美脲后血清胰岛素水平上升,其升高程度与给药剂量正相关。以上结果表明格列美脲能刺激胰岛并增加胰岛素的分泌,对比实验表明格列美脲促胰岛素分泌作用强于格列本脲。

In order to study the blood glucose-lowing action and the affection of the insulin's secretion of the domestic glimepiride, we detected the concentrations of blood glucose and insulin and employed OGTT after oral administration of glimepiride with dose levels 2.5,5 and lOmg/kg to rats and rabbits respectively. We found that the blood glu- cose of the animals was lowered after the administration (P < 0. 01) and the blood glucose-lowing action was much stronger than that of the glibenclamide. Glimepride could counteract with the blood glucose-increasing action of OGTT in rats and rabbits after given glucose orally and its counteraction depended on the dosage. Glimepride also increased the blood iasulin, which also depended on the dosage. The results above indicated that glimepride can stimulate pancreatic islets to secret insulin.