肝硬化病人血清TNF-α.Ⅳ型胶原蛋白水平的研究

A study on serum levels of type IV collagen and TNF-a in patients with liver cirrhosis

目的:为探讨肝硬化病人Ⅳ型胶原(CⅣ)和肿瘤坏死因子(TNF-a)在肝硬化病中的临床意义。方法:对30例肝硬化病人应用双抗体夹心法检测血清CⅣ.TNF-a水平。结果:肝硬化病人血清CⅣ·TNF-a含量较对照组升高(P<0.05),血清CⅣ与TNF含量两者变化相一致。结论:血清CⅣ含量升高能反映肝纤维化的程度,TNF-a参与肝纤维化的形成。

Objective: To study the clinical significance ot serum type IV collagen (C IV) and INF-a levels in patients with liver cirrhosis. Methods: Serum levds of CIV and TNF-a were measured by means of EILSA. Results:The serum levels of CW and TNF-a in patients with liver cirrhosis were higher than that in controls (P<0. 05). Conculusions: The increase of serum concentration of CIV may indicate early fibro-genic tendency in patients with liver cirrhosis. TNF-a was involved in the formation of hapatic fibrosis.