A Novel Nucleophilic Substitution of 3-Halo-6-phenoxypyridazines 被引量：1

A Novel Nucleophilic Substitution of 3-Halo-6-phenoxypyridazines

下载PDF

导出

摘要 A novel nucleophilic substitution of pyridazines is found, in which phenoxy group is dislodged rather than the halogen atom, on treating 3-halo-6-phenoxypyridazines with alkoxy anion. The reactivity of substituents on benzene ring and the halogen atom of pyridazines are studied. Reasonable explanation based on the quantum chemical calculations are given. A novel nucleophilic substitution of pyridazines is found, in which phenoxy group is dislodged rather than the halogen atom, on treating 3-halo-6-phenoxypyridazines with alkoxy anion. The reactivity of substituents on benzene ring and the halogen atom of pyridazines are studied. Reasonable explanation based on the quantum chemical calculations are given.

作者 Kang Tat REN Hut Ying LI Jun QI Hong Hai SONG Xiang WANG Hua Zheng YANG(Institute of Elemento-Organic Chemistry,State Key Laboratory of Elemento-Organic Chemistry, Tianjin, 300071)

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第1期13-14,共2页 中国化学快报（英文版）

关键词 nucleophilic substitution 3-halo-6-phenoxypyridazines MECHANISMS nucleophilic substitution 3-halo-6-phenoxypyridazines mechanisms

分类号 O625 [理学—有机化学]

引文网络
相关文献

同被引文献24

1刘万章,张在新.α-氰基丙烯酸酯瞬间胶粘剂的现状和展望[J].中国胶粘剂,2007,16(2):41-44. 被引量：18
2余先纯.α-氰基丙烯酸酯合成及改性工艺的研究[J].辽宁化工,2007,36(4):227-229. 被引量：9
3张向宇．胶粘剂分析与测试技术[M]．北京：化学工业出版社，2004：345．
4Narang U, Mainwaring L, Spath G, et akin-vitro analysis for microbial barrier properties of 2-octyl cyanoacrylate- derived wound treatment films[J].Journal of Cutaneous Medicine and Surgery:Incorporating Medical and Surgical Dermatology, 2003,7 ( 1 ) : 13-19.
5Donkerwolcke M, Burny F, Muster D.Tissues and bone adhesives-historical aspects[J].Biomaterials, 1998,19(16) : 1461-1466.
6刘H.可吸收性A-氰基丙烯酸酯组合物:中国,101180085[P].2008-05-14.
7Silvestri A, Brandi C, Grimaldi L, et al.Oetyl-2-cyanoacry- late adhesive for skin closure and prevention of infection in plastic surgery[J].Aesthetic Plastic Surgery, 2006,30(6) : 695-699.
8Sebesta M J, Bishoff J T.Octylcyanoacrylate skin closure in laparoscopy[J]. Journal of Society of Laparoendoscopic Surgeons, 2004,8 ( 1 ) : 9-14.
9Kosar A, Oguz Kapicibasi H, Levent Alpay A, et al.The experimental use of n-butyl cyanoacrylate tissue adhesive in pulmonary wedge resections[J].Heart, Lung and Circu- lation,2012,21 (11) :711-714.
10伍林,陶新,易德莲,等.一种无水酚醛树脂及其生产方法:中国,101423593[P].2009-05-06.

引证文献1

1胡盼,伍林,童坤,易德莲,秦晓蓉.无溶剂法混合催化剂催化多聚甲醛合成α-氰基丙烯酸酯[J].中国胶粘剂,2015,24(10):35-39. 被引量：1

二级引证文献1

1陈亚桥,伍林,童坤,丁建强,李泽亚,张琪,张军锋,刘盈,饶文昊,李亚伟.α-氰基丙烯酸正丁酯合成工艺的优化探究[J].中国胶粘剂,2017,26(12):12-16. 被引量：3

1于杰辉,徐吉庆,宋玉江,别海英,卢静,王铁钢.Syntheses and Characterization of Several Copper-halo Clusters[J].Chinese Journal of Chemistry,2005,23(8):1030-1036.
2陈吉之,闫超.饲料中9种磺胺类药物的HPLC法快速分离与检测[J].中国医药工业杂志,2015,46(8):892-894. 被引量：10
3Qiao Sheng HU and Chang Ming HU(Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,354 Fengling Lu,Shanghai,200032).Synthesis of Ethyl 3-Fluoroalkyl-3-Halo Acrylate With CH_2N_2[J].Chinese Chemical Letters,1997,8(8):673-676.
4Lin Jing YANG,Xiao Yuan FU,Shao Wen ZHANG (Department of Chemistry.Beijing Normal University. Beijing 00875).THEORETICAL STUDIES ON NUCLEOPHILIC VINYLICHALIDE SUBSTITUTION[J].Chinese Chemical Letters,1996,7(7):631-634.
5WANG Shu-fang, HUANG Chu-bao and ZHANG Dong (Department of Chemistry, Jilin University, Changchun, 130023).Nucleophilic Substitution of Halogenonitrobenzenes by Electrogenerated O_2- on Carbon Gas-diffusion-electrode[J].Chemical Research in Chinese Universities,1992,8(4):473-476.
6Zhao ZHANG,Zhao Bin CHEN,Qin CHANG,Fu JIN (Department of Chemistry, Shanxi University, Taiyuan 030006).Photostimulated S_(RN) 1 Reactions of Benzyl Chloride with Carbazolyl Nitrogen Anion[J].Chinese Chemical Letters,2000,11(2):97-98.
7程小波,成昌梅,王如骥,郝戬.Single-crystal Cultivation and Structure Analysis of Unstable 1-Azido-2-chloro-4-nitrobenzene[J].Chinese Journal of Structural Chemistry,2014,33(12):1801-1806.
8LU,Xi-Yan ZHU,Guo-Xin MA,Sheng-Ming Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032.A novel regio-and stereo-specific hydrohalogenation reaction of 2-alkynoic acids and their derivatives[J].Chinese Journal of Chemistry,1993,11(3):267-271.
9Gui Sheng DENG Chun Yu LIU.One-pot Approach to the Conversion of Alcohols into α-Halo-α, β-unsaturated Esters[J].Chinese Chemical Letters,2006,17(3):329-332.
10林润锋,张珩,钟武.2-(2-(6-氯己氧基)乙氧基)乙氨的合成[J].化学试剂,2011,33(2):161-163.

Chinese Chemical Letters

1999年第1期

浏览历史

内容加载中请稍等...

A Novel Nucleophilic Substitution of 3-Halo-6-phenoxypyridazines 被引量：1

同被引文献24

引证文献1

二级引证文献1

相关作者

相关机构

相关主题

浏览历史