Small Peptide Interacting with Pollen Calmodulinand their Effects on Cellular Functions

Small Peptide Interacting with Pollen Calmodulin and their Effects on Cellular Functions

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摘要 The interaction between dansyl-labeled pollen calmodulin (D-pCaM) and synthesized peptides was studied in the presence of Ca2+ by fluorescence spectra. It is Found that Gly/L-Ala --> D-Ala substitution in peptide chains caused great changes in their affinity for pCaM. Besides. our data provided evidence on the dissimilarity of different CaMs although they have highly-conserved structures. A preliminary study was carried out on the effects of CaM-binding peptides on cellular signal transduction, cell proliferation, showing the participation of CaM in cell functions mentioned above. The interaction between dansyl-labeled pollen calmodulin (D-pCaM) and synthesized peptides was studied in the presence of Ca2+ by fluorescence spectra. It is Found that Gly/L-Ala --> D-Ala substitution in peptide chains caused great changes in their affinity for pCaM. Besides. our data provided evidence on the dissimilarity of different CaMs although they have highly-conserved structures. A preliminary study was carried out on the effects of CaM-binding peptides on cellular signal transduction, cell proliferation, showing the participation of CaM in cell functions mentioned above.

作者 Jing SU Yan Ling SONG Min HU(College of Chemistry and Molecular Engineering, Peking University, Beijing 100871)(State Key Laboratory of Environmental Simulation and Pollution Control,Peking University. Beijing 100871)

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第11期929-932,共4页 中国化学快报（英文版）

关键词 pollen calmodulin AFFINITY cellular signal transduction cell proliferation pollen calmodulin affinity cellular signal transduction cell proliferation

分类号 O629 [理学—有机化学]

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Chinese Chemical Letters

1999年第11期

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Small Peptide Interacting with Pollen Calmodulinand their Effects on Cellular Functions

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